Coleman did not practice all week due to a neck injury.
The third-year wideout, who has never missed a game, had only 23 receptions with three touchdowns during the regular season.
However, Coleman came up big in last weekend's wild-card win over the Carolina Panthers with four catches for 44 yards. Willie Snead is expected to see additional playing time in Coleman's absence.
Saints linebacker Michael Mauti and third-string quarterback Taysom Hill also did not practice Friday and were both listed as questionable due to illness.